MED12 mutations in leiomyosarcoma and extrauterine leiomyoma
نویسندگان
چکیده
منابع مشابه
Preoperative Diagnosis of Usual Leiomyoma, Atypical Leiomyoma, and Leiomyosarcoma
Uterine smooth muscle tumors (SMTs) are common pelvic tumors in women, and most of them are diagnosed as usual leiomyoma (UL). Exclusion of malignant disease is important in the management of SMTs. However, differentiation of SMTs remains difficult. In this study, we aimed to improve the preoperative diagnosis of SMTs. We examined 21 ULs, 7 atypical leiomyomas (ALs), and 6 leiomyosarcomas (LMSs...
متن کاملGastric leiomyoma and leiomyosarcoma-five cases
Introduction Smooth muscle tumours are considerably less common than mucosal tumours of the stomach. An incidence of gastric leiomyomas of 16% has been found at post-mortem (McNeer and Pack, 1967a) but they are less important clinically; leiomyosarcomas are said to account for approximately 1% of all gastric malignancies (McNeer and Pack, 1967b; Ming, 1973). Clinical and histological differenti...
متن کاملGastric leiomyoma and leiomyosarcoma--five cases.
Five patients with smooth muscle tumours of the stomach are presented. In 3 cases, histological identification of the lesion was made pre-operatively on biopsy material obtained under direct vision at gastroscopy.
متن کاملMissense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma.
Uterine leiomyoma (UL), the most common benign tumour found in females, is associated with many recurrent genetic aberrations, such as translocations, interstitial deletions and specific germline mutations. Among these, mutations affecting exon 2 of the mediator complex subunit 12 (MED12) gene are commonly detected in the majority of ULs. Mutational analysis of the MED12 gene, performed on 36 U...
متن کاملmicroRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells
Aberrant expression of microRNAs (miRNAs), including miR-21, and alteration of their target genes stability have been associated with cellular transformation and tumorigenesis. We investigated the expression, regulation and function of miR-21 in leiomyomas which develop from myometrial cellular transformation. The results indicated that miR-21 is over-expressed in leiomyomas with specific eleva...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2012
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2012.203